[Effect of Gastropulgit on intragastric pH values. Telemetric study using the Heidelberg capsule]

Using a "quasi physiological" examination technique (Heidelberg capsule in free passage), the influence of Gastropulgit on the intragastral pH value was measured in comparison with 3 mEq/L sodium bicarbonate (NaHCO3), involving 147 patients. The following results were obtained. 1. Contrary to NaHCO3, Gastropulgit results in a very constant compensation of the gastric pH level to weakly acid values. 2. The return of acid gastric medium after administration of Gastropulgit is slower in the case of weaker neutralization. As opposed to NaHCO3, the initial pH value was not reached as an average. 3. Over and beyond the actual duration of its effect, Gastropulgit also has an effect on gastric function, whose total duration could not be evaluated using the present technique. A trial neutralization employing NaHCO3 after termination of the Gastropulgit reaction shows an absence of high alkalization. On average, only weakly acid values were obtained. The return to a less acid pH value constitutes the second effect. According to these results, Gastropulgit appears to balance out a physiologically stimulated gastric function. It is not yet possible to provide evidence of an adaptation to physiological conditions, as these are not yet sufficiently known. One may assume, however, that the compensation of acid stimulation after the neutralization phase is a part of the process. As a result of the effects over and beyond the actual effective period - an influence on subsequent neutralization attempts - one may surmise that the administration of a gastric therapeutic agent which also neutralizes acids, such as Gastropulgit, may also be justified prior to the intake of a meal, and that it promises a favourable therapeutic effect when used in a broad range.