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Related Experiment Videos

Delayed pericardial disease after radiotherapy

M M Applefeld, R G Slawson, M Hall-Craigs

    The American Journal of Cardiology
    |February 1, 1981
    PubMed
    Summary

    Radiotherapy can cause delayed constrictive pericarditis years later, presenting as exertional dyspnea. Early recognition and cardiovascular examination are crucial for diagnosing this radiation-induced heart condition.

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    Area of Science:

    • Cardiology
    • Oncology
    • Radiology

    Background:

    • Radiotherapy is a common cancer treatment.
    • Delayed complications of radiotherapy can affect the heart.
    • Constrictive pericarditis is a serious cardiac condition.

    Purpose of the Study:

    • To describe the clinical presentation and outcomes of patients with delayed constrictive pericarditis after radiotherapy.
    • To highlight the diagnostic challenges and management strategies for radiation-induced pericardial disease.

    Main Methods:

    • Retrospective case series of seven patients.
    • Review of clinical data, including symptoms, physical examination, cardiac catheterization, and treatment outcomes.
    • Analysis of the time interval between radiotherapy and the onset of constrictive pericarditis.

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    Main Results:

    • Seven patients developed constrictive pericarditis 51-268 months post-radiotherapy.
    • Exertional dyspnea was the most common symptom, often misdiagnosed as mediastinal fibrosis.
    • Cardiac catheterization confirmed constrictive pericarditis in all patients.
    • Pericardiectomy outcomes varied, with two excellent results and two deaths from unrelated causes.

    Conclusions:

    • Delayed constrictive pericarditis is a significant long-term complication of radiotherapy.
    • Clinical suspicion and thorough cardiovascular examination are essential for early diagnosis.
    • Management requires a multidisciplinary approach, with surgical intervention offering potential benefits but carrying risks.