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Related Experiment Videos

Radionuclide regurgitant index: value and limitations

W Lam, D Pavel, E Byrom

    The American Journal of Cardiology
    |February 1, 1981
    PubMed
    Summary

    The radionuclide regurgitant index can predict left-sided valve regurgitation severity. However, it showed discordance in patients with low ejection fraction or mitral valve prolapse.

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    Area of Science:

    • Cardiology
    • Nuclear Medicine
    • Medical Imaging

    Background:

    • The radionuclide regurgitant index (LV/RV stroke counts from gated equilibrium studies) is a non-invasive method to assess left-sided valve regurgitation.
    • Previous studies suggest its utility in predicting the presence and severity of mitral or aortic regurgitation.

    Purpose of the Study:

    • To evaluate the accuracy of the radionuclide regurgitant index in grading left-sided valve regurgitation.
    • To identify patient subgroups where the radionuclide regurgitant index may be discordant with angiographic findings.

    Main Methods:

    • 100 patients with left-sided valve regurgitation underwent angiographic grading (0-4+).
    • Radionuclide regurgitant index was calculated using gated equilibrium studies.
    • Comparison between radionuclide regurgitant index values and angiographic grades of regurgitation.

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    Main Results:

    • A significant correlation was found between the radionuclide regurgitant index and angiographic regurgitation severity (p < 0.05).
    • Mean radionuclide regurgitant index increased with higher regurgitation grades.
    • Twelve patients (12%) showed discordant results, with higher rates in those with low ejection fraction (<0.30) or mitral valve prolapse with ventricular extrasystoles.

    Conclusions:

    • The radionuclide regurgitant index is a valuable tool for assessing left-sided valve regurgitation severity.
    • Caution is advised in interpreting the radionuclide regurgitant index in patients with significantly reduced left ventricular ejection fraction or specific arrhythmias like mitral valve prolapse with frequent ventricular extrasystoles, as discordance is more likely.