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Renal glomerular function and long-term lithium therapy

J R Depaulo, E I Correa, D G Sapir

    The American Journal of Psychiatry
    |March 1, 1981
    PubMed
    Summary
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    Lithium therapy may impact kidney function. This study found declining glomerular filtration rate (GFR) in some patients, recommending creatinine clearance tests for monitoring kidney health during long-term lithium treatment.

    Area of Science:

    • Nephrology
    • Psychiatry
    • Pharmacology

    Background:

    • Glomerular filtration rate (GFR) assessment in lithium-treated patients shows variability.
    • Lithium is a common treatment for manic-depressive illness, necessitating monitoring for potential side effects.

    Purpose of the Study:

    • To quantitatively assess GFR in lithium-treated patients.
    • To investigate the relationship between lithium therapy duration and renal function.

    Main Methods:

    • Tested 99 lithium-treated patients using multiple GFR measurement techniques.
    • Included creatinine clearance and Cockcroft GFR calculations.
    • Analyzed correlations between serum creatinine, GFR, and lithium treatment duration.

    Main Results:

    Related Experiment Videos

    • Ten of 86 patients without prior renal disease exhibited reduced creatinine clearance.
    • Found significant, non-age-related correlations between serum creatinine, Cockcroft GFR, and lithium therapy duration.
    • Serum creatinine alone was insufficient for sensitive GFR monitoring.

    Conclusions:

    • Chronic lithium therapy may be associated with a decline in GFR.
    • Recommends duplicate creatinine clearances, confirmed by Cockcroft values, for monitoring GFR in lithium-treated patients.
    • Highlights the need for vigilant renal function assessment during long-term lithium use.