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[Semiologic value of erythrocyte macrophages in the cerebrospinal fluid]
Abstract:
An investigation was made in the cerebrospinal fluid of 82 patients who had bleeding into the subarachnoid space or other neurologic disorders in order to study the macrophages. The ages of these patients ranged from 24 hours to 80 years. It was verified that the macrophages with red blood cell could be demonstrated from 24 hours until 30 days after the onset of the bleeding. The macrophages with hemosiderin were observed after the 6th day after the onset of the bleeding, and they could be seen in some cases after 70 days. It was discussed the assertion that the simultaneous presence of red blood cell and hemosiderin in the cytoplasm always indicates repeated hemorrhage. In a 24-hour-old newborn baby with bleeding in the subarachnoid space it was found macrophage with hemosiderin. This anomalous finding pointed out to hemorrhage during the intrauterine life.
Insights
Macrophages in cerebrospinal fluid indicate subarachnoid hemorrhage timing. Hemosiderin-laden macrophages appear after six days, while red blood cells are visible up to 30 days post-bleeding.
Area of Science:
- Neurology
- Pathology
- Cell Biology
Context:
- Cerebrospinal fluid analysis is crucial for diagnosing neurological disorders.
- Macrophages play a significant role in clearing cellular debris after hemorrhage.
- Understanding macrophage behavior in cerebrospinal fluid aids in determining the timing and nature of neurological events.
Purpose:
- To investigate the temporal presence of macrophages containing red blood cells and hemosiderin in the cerebrospinal fluid of patients with subarachnoid hemorrhage.
- To analyze the diagnostic utility of these findings for differentiating acute versus chronic bleeding events.
- To explore the implications of hemosiderin presence in macrophages in neonates.
Summary:
- Macrophages containing red blood cells were detected in cerebrospinal fluid from 24 hours to 30 days post-hemorrhage.
- Macrophages with hemosiderin were observed from day 6 up to 70 days after bleeding onset.
- A case of a newborn with hemosiderin-laden macrophages suggested intrauterine hemorrhage, challenging typical timelines.
Impact:
- Provides a timeline for macrophage-based detection of subarachnoid hemorrhage.
- Offers insights into differentiating recurrent hemorrhages.
- Highlights the potential for diagnosing intrauterine bleeding events through cerebrospinal fluid analysis.