Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple organ involvement in perinatal asphyxia

A Martín-Ancel1, A García-Alix, F Gayá

  • 1Department of Pediatrics, La Paz Children's Hospital, Autonoma University of Madrid, Spain.

The Journal of Pediatrics
|November 1, 1995
PubMed
Summary

The Apgar score at 5 minutes is a key indicator for identifying newborns at risk of multisystem dysfunction following perinatal asphyxia. This score helps predict the severity and extent of organ involvement in affected infants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ten years since the introduction of therapeutic hypothermia in neonates with perinatal hypoxic-ischaemic encephalopathy in Spain.

Neurologia·2022
Same author

Bedside and laboratory neuromonitoring in neonatal encephalopathy.

Seminars in fetal & neonatal medicine·2021
Same author

Ten years since the introduction of therapeutic hypothermia in neonates with perinatal hypoxic-ischaemic encephalopathy in Spain.

Neurologia·2020
Same author

Associations between neural injury markers of intrauterine growth-restricted infants and neurodevelopment at 2 years of age.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2018
Same author

Infratentorial congenital glioblastoma multiforme. A rare tumour with a still unknown biology.

Revista de neurologia·2016
Same author

[In memoriam. Claudine Amiel-Tison].

Anales de pediatria (Barcelona, Spain : 2003)·2015

Area of Science:

  • Neonatology
  • Pediatric Critical Care
  • Perinatal Medicine

Background:

  • Perinatal asphyxia is a significant cause of neonatal morbidity and mortality.
  • Multisystem dysfunction is a common complication following perinatal asphyxia, affecting various organs.
  • Identifying reliable markers for predicting organ involvement is crucial for timely intervention.

Purpose of the Study:

  • To determine the incidence and severity spectrum of multisystem dysfunction in term newborns after perinatal asphyxia.
  • To investigate the correlation between clinical and biochemical indicators of perinatal asphyxia and the extent of multiorgan damage.

Main Methods:

  • Prospective study of 72 term newborns diagnosed with perinatal asphyxia.
  • Systematic evaluation of neurological, renal, pulmonary, cardiac, and gastrointestinal systems.

Related Experiment Videos

  • Classification of organ involvement as moderate or severe.

    • Main Results:

    • Multisystem organ involvement occurred in 82% of infants; the central nervous system (CNS) was most affected (72%).
    • Severe CNS injury was associated with other organ involvement, while moderate CNS involvement could be isolated.
    • Apgar scores at 1 and 5 minutes were the only perinatal factors linked to the number and severity of organ involvement, with the 5-minute Apgar score showing a stronger independent association.

    Conclusions:

    • The Apgar score at 5 minutes is a valuable perinatal marker for identifying infants at risk of organ dysfunction following perinatal asphyxia.
    • Clinical assessment using the Apgar score can aid in stratifying risk and guiding management in neonates exposed to asphyxia.