Long-term venous access using endogenous splenic tissue: the 'spleen-o-port'

Area of Science:

• Surgical Innovation
• Vascular Access
• Biomedical Engineering

Background:

• Central venous catheters and ports are prone to complications like infection and thrombosis.
• There is a need for alternative long-term venous access solutions, particularly for immunocompromised patients.

Purpose of the Study:

• To evaluate the feasibility and safety of using endogenous splenic tissue as a subcutaneous port for long-term venous access.
• To assess the spleen-o-port's functionality for drug delivery and blood sampling.

Main Methods:

• A spleen-o-port was created in puppies by implanting the inferior pole of the spleen into a subcutaneous pocket.
• The spleen's vascular supply was preserved, and the port's function was monitored over six months.
• Imaging, blood sampling, and drug infusion studies were conducted to assess patency and efficacy.

Main Results:

• The spleen-o-port demonstrated no deaths, infections, ruptures, or thromboses over a six-month observation period.
• Contrast agent successfully visualized splenic and portal vein filling, indicating good vascular flow.
• Electrolyte levels from port samples matched peripheral samples, and drug infusion achieved therapeutic levels.

Conclusions:

• The spleen-o-port serves as a functional and safe alternative to traditional central venous access devices.
• This approach eliminates the foreign body associated with conventional ports, potentially reducing septic complications.
• The spleen-o-port facilitates efficient drug administration and serial blood sampling for long-term venous access needs.