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Evolution of longevity in mammals

¹Department of Pathology, Northwestern University Medical School, Chicago, IL 60611-2611, USA.

Mechanisms of Ageing and Development

|June 30, 1995

Summary

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Species exhibit maximum life spans, with diverse longevity evolving independently in mammals. Genetic factors for somatic maintenance and disease resistance likely contribute to extended lifespans, including humans, with significant post-reproductive periods.

Area of Science:

Evolutionary biology
Genetics
Gerontology

Background:

Maximum life span varies across mammalian species and orders.
Understanding the evolutionary drivers of longevity is crucial.

Purpose of the Study:

To explore the independent evolution of long-lived species clusters.
To identify potential genetic mechanisms underlying extended maximum life spans.

Main Methods:

Comparative analysis of mammalian life span data.
Review of genetic factors related to aging and mortality.

Main Results:

Evidence suggests independent evolution of longevity in related species groups.
Genes involved in somatic maintenance and disease resistance are implicated.

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Human longevity, including its post-reproductive phase, is potentially explained by natural selection.

Conclusions:

Diverse evolutionary pathways likely contributed to maximum life span variation.
Genetic mechanisms for repair and resistance play a key role in longevity.
Natural selection may favor extended post-reproductive lifespans in certain species.