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Liquid ventilation in adults, children, and full-term neonates
R B Hirschl1, T Pranikoff, P Gauger
1Department of Surgery, University of Michigan, Ann Arbor, USA.
Lancet (London, England)
|November 4, 1995
Abstract:
We evaluated the safety and efficacy of partial liquid ventilation in a series of 19 adults, children, and neonates who were in respiratory failure and on extracorporeal life support. During partial liquid ventilation, the alveolar-arterial oxygen difference decreased from 590 (SE 25) to 471 (42) mm Hg (p = 0.0002) and static pulmonary compliance increased from 0.18 (0.04) to 0.29 (0.04) mL cm H2O-1 kg-1 (p = 0.0002). 11 patients (58%) survived. These preliminary data suggest that partial liquid ventilation can be safely used in patients with severe respiratory failure and may improve lung function.