Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A magnetization-driven gradient echo pulse sequence for the study of myocardial perfusion

R M Judd1, S B Reeder, E Atalar

  • 1Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

Magnetic Resonance in Medicine
|August 1, 1995
PubMed
Summary

This study introduces a new T1-weighted imaging sequence for myocardial perfusion studies. The novel sequence provides a stable baseline and enhanced dynamic range for contrast agent imaging.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coronary artery calcium and cardiovascular disease prediction by scanner type: the multi-ethnic study of atherosclerosis.

Clinical radiology·2022
Same author

COVID-19 outcomes in patients with antiphospholipid syndrome: a retrospective cohort study.

Bratislavske lekarske listy·2022
Same author

Deformable Known Component Model-Based Reconstruction for Coronary CT Angiography.

Proceedings of SPIE--the International Society for Optical Engineering·2021
Same author

Reproducibility of liver R2* quantification for liver iron quantification from cardiac R2* acquisitions.

Abdominal radiology (New York)·2021
Same author

Ferumoxytol-enhanced MR imaging for differentiating intrapancreatic splenules from other tumors.

Abdominal radiology (New York)·2020
Same author

Deep Brain Nuclei T1 Shortening after Gadobenate Dimeglumine in Children: Influence of Radiation and Chemotherapy.

AJNR. American journal of neuroradiology·2017

Area of Science:

  • Cardiovascular Imaging
  • Magnetic Resonance Imaging
  • Biomedical Engineering

Background:

  • Assessing myocardial perfusion is crucial for diagnosing and managing heart conditions.
  • Existing MRI sequences for perfusion imaging have limitations in baseline stability and dynamic range.
  • Optimizing MRI techniques can improve the accuracy and sensitivity of myocardial perfusion assessment.

Purpose of the Study:

  • To present and evaluate a novel T1-weighted imaging pulse sequence for contrast-enhanced myocardial perfusion MRI.
  • To demonstrate the sequence's ability to achieve a stable, homogeneous pre-contrast baseline.
  • To compare the dynamic range of the proposed sequence with existing methods.

Main Methods:

  • Developed a T1-weighted imaging sequence utilizing nonselective preparatory radiofrequency (RF) pulses to achieve steady state.

Related Experiment Videos

  • Modified a spoiled gradient-recalled echo sequence by incorporating preparatory RF pulses before image acquisition.
  • Evaluated the sequence in phantom studies and in vivo experiments to assess its performance.

    • Main Results:

    • The proposed sequence achieved a stable, homogeneous, and dark pre-contrast baseline in both tissue and blood.
    • Pixel intensity demonstrated an approximate linear relationship with 1/T1, allowing for quantitative analysis.
    • The sequence exhibited a greater dynamic range of signal response to contrast agent concentration compared to inversion-recovery fast low angle shot (IR-FLASH) sequences.

    Conclusions:

    • The developed T1-weighted imaging sequence is effective for contrast-based myocardial perfusion studies.
    • The sequence offers advantages in baseline stability and dynamic range, potentially improving diagnostic accuracy.
    • This novel sequence holds promise for enhanced clinical assessment of myocardial perfusion.