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Related Experiment Videos

Serial MRI changes in radiation myelopathy

P Y Wang1, W C Shen, J S Jan

  • 1Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan.

Neuroradiology
|July 1, 1995
PubMed
Summary

Radiation myelopathy after nasopharyngeal carcinoma radiotherapy causes cervical spinal cord signal changes and swelling on MRI. Follow-up shows atrophy, with no clear link between imaging and clinical symptoms.

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Area of Science:

  • Radiology
  • Neurology
  • Oncology

Background:

  • Radiation myelopathy is a serious complication following radiotherapy for nasopharyngeal carcinoma.
  • Cervical spinal cord involvement can lead to significant neurological deficits.

Purpose of the Study:

  • To assess serial Magnetic Resonance Imaging (MRI) changes in the cervical spinal cord of patients with radiation myelopathy.
  • To correlate MRI findings with clinical manifestations and disease progression.

Main Methods:

  • Serial MRI scans (T1-weighted, T2*-weighted, contrast-enhanced) were performed on seven patients (2 men, 5 women; aged 40-77) with radiation myelopathy.
  • Imaging was conducted 1-4 months post-symptom onset and at follow-up (2-22 months).

Main Results:

  • Initial MRI revealed low T1 signal, high T2* signal, and focal contrast enhancement at C1-2 in all patients.
  • Spinal cord swelling was present in five patients.
  • Follow-up showed persistent signal changes, variable contrast enhancement, and eventual atrophy at C1-2, appearing as early as 10 months post-onset.
  • No correlation was found between clinical symptoms and spinal cord atrophy on MRI.

Conclusions:

  • MRI demonstrates characteristic signal alterations, swelling, and eventual atrophy in the cervical spinal cord in radiation myelopathy.
  • Serial imaging is valuable for monitoring disease progression, although clinical correlation with atrophy is limited.

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