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Outcome analysis for lip carcinoma

R P Zitsch1, C W Park, G J Renner

  • 1Department of Surgery, University of Missouri Hospital, Columbia, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|November 1, 1995
PubMed
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Lip cancer survival depends on tumor size, grade, and location. Aggressive treatment is recommended for larger, high-grade, or upper lip tumors, especially in women, to improve outcomes.

Area of Science:

  • Oncology
  • Head and Neck Surgery
  • Dermatology

Background:

  • Lip carcinoma is a common oral cancer, often curable but with potential for recurrence and metastasis.
  • Understanding prognostic factors is crucial for effective lip cancer management.

Purpose of the Study:

  • To identify and rank prognostic variables in lip cancer.
  • To clarify gender-based differences in lip cancer site predilection.
  • To examine the correlation between tumor site and histopathology.

Main Methods:

  • Retrospective review of 1252 patients diagnosed with lip cancer between 1940 and 1987.
  • Analysis of prognostic variables, including tumor size, grade, adenopathy, site, and surgical margins.
  • Evaluation of recurrence rates and survival outcomes based on tumor characteristics and treatment.

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Main Results:

  • Large tumor size (>3 cm), high tumor grade, adenopathy, upper lip/commissure location, and positive margins negatively impact survival.
  • Upper lip cancers are more common in women (21%) than men (3%); basal cell carcinoma is more frequent on the upper lip.
  • Recurrence (15.1%) is linked to large size and poor differentiation, with regional recurrence significantly reducing survival (52% vs. 78% for local).

Conclusions:

  • Aggressive treatment is warranted for large (>3 cm), high-grade, upper lip/commissure lip cancers, and those with cervical lymphadenopathy.
  • Lip cancer in women may exhibit slightly more aggressive behavior.
  • Prognostic factors identified can guide clinical decision-making and improve patient outcomes.