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Multiple primary melanomas: data and significance

S Ariyan1, W J Poo, J Bolognia

  • 1Yale Melanoma Unit, Yale University School of Medicine, New Haven, Conn, USA.

Plastic and Reconstructive Surgery
|November 1, 1995
PubMed
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Patients developing a second melanoma often have thin, early-stage lesions. Multiple melanomas do not worsen prognosis, which remains tied to the initial or thickest melanoma.

Area of Science:

  • Dermatology
  • Oncology
  • Cancer Epidemiology

Background:

  • Melanoma incidence is rising, with a significant percentage of patients developing secondary primary melanomas.
  • Approximately 5% of patients with primary cutaneous melanoma develop another primary melanoma in their lifetime.

Purpose of the Study:

  • To analyze the characteristics and outcomes of patients with multiple primary cutaneous melanomas.
  • To understand the timing, thickness, and prognostic implications of secondary melanomas.

Main Methods:

  • Retrospective analysis of 27 patients with 59 primary cutaneous melanomas at the Yale Melanoma Unit.
  • Detailed review of patient data including diagnosis timing, lesion thickness, and follow-up information.

Main Results:

Related Experiment Videos

  • Of 27 patients, 22 developed a second primary melanoma and 5 developed three.
  • Second primary melanomas were synchronous in 30% of cases and metachronous in the majority.
  • All subsequent melanomas were in situ or less than 1.0 mm thick, regardless of the initial melanoma's thickness.

Conclusions:

  • Patients with multiple melanomas typically develop thin, early-stage secondary lesions.
  • Developing multiple melanomas does not negatively impact prognosis; it remains determined by the initial or thickest melanoma.