[The N-cholinergic activation of the periodic activity of excitable structures in early postnatal ontogeny]

The influence of central N-cholinomimetics on the nature of respiratory rhythm has been studied on 0-16 day rats. It was established that lobeline injection (50 mg/kg) in the rats caused the replacement of background near-second respiratory rhythm by periodic respiration with the period of initiation of respiratory movement complexes of the order of 10-15 sec. Nicotine injection (5 mg/kg) caused less marked effect. On the basis of the present research and available data (the influence of N-cholinomimetics on the spontaneous motor activity and heart rhythm) in was inferred the direct participation of central N-cholinergic structures in reproduction of primary excitement rhythms including the rhythms with the period of 1 and 5-15 sec. The hypothesis on the unity of mechanisms forming the basis of generation of periodic excitement in different excitable structures has been put forward. It was proposed that cholinergic transmitter systems took part in the generation of primary rhythms.