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Related Experiment Videos

Pheocromocytoma and gastrointestinal bleeding

E Vázquez-Quintana1, R Vargas, M Pérez

  • 1Department of Surgery, University of Puerto Rico School of Medicine, San Juan, Puerto Rico 00936-5067.

The American Surgeon
|November 1, 1995
PubMed
Summary

Extra-adrenal pheochromocytoma can cause gastrointestinal bleeding, a rare complication. This case highlights a large, unresectable tumor presenting with duodenal varices and bleeding, emphasizing the need for awareness.

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Oncology

Background:

  • Pheochromocytomas are rare neuroendocrine tumors typically arising in the adrenal medulla.
  • Extra-adrenal pheochromocytomas can occur along the sympathetic chain, presenting with diverse clinical manifestations.
  • Gastrointestinal bleeding is an uncommon complication of pheochromocytoma.

Observation:

  • A 46-year-old male presented with an abdominal mass and gastrointestinal bleeding without a history of hypertension.
  • Imaging revealed a large, calcified right paravertebral mass, confirmed as an unresectable pheochromocytoma.
  • Endoscopy identified duodenal varices, suggesting a potential link to the tumor's vascular involvement.

Findings:

  • Biopsy confirmed the mass as a pheochromocytoma.

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  • The patient experienced postoperative pulmonary edema and recurrent gastrointestinal bleeding and heart failure.
  • Despite unresectability, the patient survived for 5 years with medical management.

    • Implications:

    • This case underscores the rare but serious gastrointestinal complications associated with pheochromocytomas.
    • It highlights the importance of considering pheochromocytoma in patients with unexplained abdominal masses and gastrointestinal bleeding.
    • Further research into the mechanisms and management of gastrointestinal complications of pheochromocytoma is warranted.