Related Experiment Videos
[Local cutaneous necrosis after injection of interferon beta]
F Bérard1, S Canillot, B Balme
1Service de Dermatologie, Hôpital de l'Hôtel-Dieu, Lyon.
Annales De Dermatologie Et De Venereologie
|January 1, 1995
Abstract
Introduction:
Skin necrosis at the site of interferon injections is unusual. With beta-interferon, it has been observed with high doses ranging from 90 to 180 millions daily.
Case Report:
Is reported a case of abdominal skin necrosis following 6 months treatment with beta-interferon injections, 9 millions 3 times a week, in a 56 years-old man with chronic type C hepatitis. Histological analysis showed fibrin thrombosis of deep dermal vessels. There was no coagulation abnormality.
Discussion:
The mechanisms of the interferon induced skin necrosis are discussed.