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Microvascular invasion in prostate cancer correlates with pathologic stage
D R Salomao1, S D Graham, D G Bostwick
1Department of Pathology, Mayo Clinic, Rochester, Minn 55905, USA.
Archives of Pathology & Laboratory Medicine
|November 1, 1995
Summary
Microvascular invasion is common in prostate cancer, found in 53% of cases. Its presence strongly correlates with higher pathological stage and poorer prognostic factors.
Area of Science:
- Uropathology
- Oncology
- Surgical Pathology
Background:
- Prostate carcinoma prognosis is influenced by various pathological factors.
- Microvascular invasion (MVI) is a critical indicator of tumor aggressiveness.
Purpose of the Study:
- To determine the incidence of microvascular invasion in prostate cancer.
- To investigate the correlation between MVI and other prognostic factors.
Main Methods:
- Analysis of 210 whole-mounted radical prostatectomies using routine light microscopy.
- Evaluation of the frequency and extent of microvascular invasion.
Main Results:
- Microvascular invasion was identified in 53% of specimens (111/210).
- Both focal and extensive MVI correlated significantly with capsular perforation, seminal vesicle involvement, and lymph node metastases.
- MVI showed a strong positive correlation with surgical margin status, Gleason score, and tumor volume.
Conclusions:
- Microvascular invasion in prostate cancer is positively associated with adverse pathological stage indicators.
- Reporting MVI in prostate specimens is recommended by the Cancer Committee of the College of American Pathologists.