Tumor immunity following cryosurgery or electrocauterization

Cryosurgery of MCA-10 in C57BL mice resulted in significantly greater humoral and lymphocyte-mediated cytotoxicity to MCA-10 target cells than in untreated, tumor-bearing mice or animals which had undergone tumor amputation. This result was tumor specific and could be reproduced by treatment of the tumor-bearing and amputated mice with frozen exogenous tumor antigen. A similar response was produced by electrocauterization of tumor.