Related Experiment Video

Updated: Aug 12, 2026

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
09:58

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side

Published on: May 6, 2016

Antibacterial agents in infections of the central nervous system and eye

A G Papastamelos1, A R Tunkel

  • 1University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford, USA.

Infectious Disease Clinics of North America
|September 1, 1995
PubMed

Insights

Antimicrobial therapy for central nervous system and eye infections requires drugs that penetrate barriers like the blood-brain barrier. This review covers principles and recommendations for treating these specific infections.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Neurology
  • Ophthalmology

Background:

  • Experimental animal models are crucial for understanding antimicrobial therapy in central nervous system (CNS) and ocular infections.
  • Effective antimicrobial treatment for meningitis necessitates agents that cross the blood-brain barrier and are active in cerebrospinal fluid.
  • Ocular infection treatment involves overcoming drug penetration barriers or utilizing alternative administration routes like periocular or intravitreal injections.

Purpose of the Study:

  • To review fundamental therapeutic principles for treating CNS and eye infections.
  • To provide evidence-based recommendations for managing specific central nervous system and ocular infections.

Main Methods:

  • Literature review of antimicrobial therapy principles.
  • Analysis of drug penetration and activity in CNS and ocular environments.
  • Synthesis of treatment recommendations for specific infections.

Main Results:

  • Efficacy in meningitis therapy depends on blood-brain barrier penetration, activity in purulent cerebrospinal fluid, and rapid bactericidal action.
  • Optimal ocular therapy requires topical drug penetration or bypassing barriers via periocular/intravitreal routes.
  • Key therapeutic principles and specific infection treatment guidelines are presented.

Conclusions:

  • Understanding drug pharmacokinetics and pharmacodynamics is vital for successful antimicrobial therapy in CNS and ocular infections.
  • Tailored therapeutic strategies are essential for effective management of meningitis and various ocular infections.
  • This review consolidates essential knowledge for clinicians treating these challenging infections.

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