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Adjuncts to antibacterial therapy

M O Frank1, G L Mandell

  • 1Indiana University School of Medicine, Indianapolis, USA.

Infectious Disease Clinics of North America
|September 1, 1995
PubMed
Summary
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Modulating the immune system offers new ways to improve antibacterial treatments. Therapies like cytokines and immune globulin can boost the immune response to fight infection effectively.

Area of Science:

  • Immunology
  • Microbiology
  • Pharmacology

Background:

  • Immune system modulation is a promising strategy for enhancing antibacterial therapy.
  • Current approaches include augmenting or attenuating the host's immune response to infection.

Purpose of the Study:

  • To explore strategies for augmenting or attenuating the immune system's response to infection.
  • To highlight the potential of immune modulation in improving antibacterial treatments.

Main Methods:

  • Review of existing and emerging immunomodulatory therapies.
  • Categorization of therapies into those that upregulate (cytokines, growth factors, interferons) or downregulate (corticosteroids) immune responses.
  • Discussion of replacement therapies like immune globulin.

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Main Results:

  • Identified cytokines (hematopoietic growth factors, interferons) as agents that upregulate immune response.
  • Recognized immune globulin as a replacement therapy.
  • Highlighted corticosteroids as agents that downregulate immune response.

Conclusions:

  • Immune system augmentation and attenuation represent promising avenues for enhancing antibacterial therapy.
  • Future strategies aim to precisely adjust the host response to maximize microbial inhibition while minimizing inflammatory damage.