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In vitro activity of the semisynthetic glycopeptide amide MDL 63,246
M T Kenny1, M A Brackman, J K Dulworth
1Marion Merrell Dow Inc., Kansas City, Missouri 64134-0627, USA.
Antimicrobial Agents and Chemotherapy
|July 1, 1995
Abstract:
The in vitro activity of the semisynthetic glycopeptide amide MDL 63,246 against 293 U.S. clinical isolates of gram-positive cocci was determined by the broth microdilution method. When compared with teicoplanin, MDL 63,246 had improved activity against Staphylococcus epidermidis (MICs that inhibited 90% strains tested [MIC90s], 0.25 versus 8 micrograms/ml, respectively). Staphylococcus haemolyticus (MIC90s, 1 versus 32 micrograms/ml, respectively), and VanA Enterococcus faecium (MIC90s, 32 versus > or = 1,024 micrograms/ml, respectively).