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Bioassay quantitation of ramoplanin in human and in nonprimate sera
M T Kenny1, M A Brackman, J K Dulworth
1Microbiology Department, Marion Merrell Dow Inc., Kansas City, Missouri 64137.
Diagnostic Microbiology and Infectious Disease
|February 1, 1994
Abstract:
This study developed and validated a bioassay for ramoplanin in human, dog, rabbit, and rat sera. Mean analyte recoveries and coefficients of variation for duplicate assays with each serum using coded and spiked (30-720 ng/ml) samples ranged from 93.5% to 106.3% and from 1.8% to 5.4% respectively. All correlation coefficients were > 0.99 and, for each serum, there was no significant difference in overall analyte recovery between the 2 test days.