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A case of multiple osteochondroma in the rat
H Iwata1, S Yamamoto, S Mikami
1Biosafety Research Center, Foods, Drugs and Pesticides, Shizuoka, Japan.
The Journal of Veterinary Medical Science
|April 1, 1995
Summary
Spontaneous multiple osteochondroma, a rare condition in rats, was observed in a control group rat during a toxicity study. Histological analysis confirmed the neoplastic nature of these progressively enlarging bone and cartilage tumors.
Area of Science:
- Veterinary Pathology
- Oncology
- Toxicology
Background:
- Spontaneous osteochondroma occurrence in rats is exceptionally rare.
- This case report details a spontaneous multiple osteochondroma in a Sprague Dawley (SD) rat.
Observation:
- A 58-week-old male SD rat from a toxicity study control group presented with multiple osteochondromas.
- Tumors were located on the right forelimb (humerus and scapula) and the right posterior rib.
Findings:
- Histological examination revealed tumors with a hyaline cartilage outer layer and a trabecular bone core with fatty marrow.
- Tumor structures were continuous with the parent bone's periosteum, cortical bone, and medullary cavity.
- Progressive enlargement indicated a neoplastic process.
Implications:
- This case expands the understanding of spontaneous bone tumor occurrence in laboratory rats.
- Highlights the importance of vigilant monitoring in toxicity studies, even in control groups.
- Contributes to the rare literature on spontaneous osteochondroma in Sprague Dawley rats.