Related Experiment Videos
Does bacitracin have an absorption-enhancing effect in the intestine?
S Gotoh1, R Nakamura, M Nishiyama
1Department of Biopharmaceutics, Kyoto Pharmaceutical University, Japan.
Biological & Pharmaceutical Bulletin
|May 1, 1995
Summary
Bacitracin, a protease inhibitor, was found to enhance the absorption of FD-4 and phenol red in rats. This suggests bacitracin possesses both protease-inhibitory and absorption-enhancing capabilities without causing harm.
Area of Science:
- Pharmacology
- Gastroenterology
- Drug Delivery
Background:
- Protease inhibitors are studied for their potential effects on drug absorption.
- Understanding intestinal absorption mechanisms is crucial for developing effective drug delivery systems.
Purpose of the Study:
- To investigate the absorption enhancement effects of three protease inhibitors: aprotinin, bacitracin, and soybean trypsin inhibitor.
- To evaluate the potential of these inhibitors to improve the absorption of model compounds in the rat intestine.
Main Methods:
- Administration of aprotinin, bacitracin, and soybean trypsin inhibitor to rats.
- Assessment of the absorption of fluorescein isothiocyanate dextran (FD-4) and phenol red.
- Evaluation of intestinal mucosal integrity and toxicity.
Main Results:
- Bacitracin significantly enhanced the absorption of FD-4 and phenol red.
- The absorption enhancement by bacitracin was observed in both the small and large intestine.
- No significant mucosal toxicity was detected with bacitracin treatment.
Conclusions:
- Bacitracin demonstrates a dual capability, acting as both a protease inhibitor and an absorption enhancer.
- Bacitracin shows promise as an agent to improve oral drug bioavailability without compromising intestinal health.