Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymeric microspheres prepared by spraying into compressed carbon dioxide

R Bodmeier1, H Wang, D J Dixon

  • 1College of Pharmacy, University of Texas at Austin 78712, USA.

Pharmaceutical Research
|August 1, 1995
PubMed
Summary

The compressed CO2 atomization (PCA) process effectively prepares polymeric microparticles, offering control over size and morphology. This method is promising for drug delivery systems, minimizing solvents and surfactants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Organocatalytic enantioselective desymmetrisation.

Chemical Society reviews·2016
Same author

Evolution of a complex coevolved trait: active pollination in a genus of fig wasps.

Journal of evolutionary biology·2004
Same author

1,2-diacetals: a new opportunity for organic synthesis.

Chemical reviews·2001
Same author

Highly diastereoselective lithium enolate aldol reactions of butane-2,3-diacetal desymmetrized glycolic acid and deprotection to enantiopure anti-2,3-dihydroxy esters.

Organic letters·2001
Same author

Highly diastereoselective Michael addition reactions of butane-2,3-diacetal desymmetrized glycolic acid. Preparation of alpha-hydroxy-gamma-amino acid derivatives.

Organic letters·2001
Same author

A short stereoselective total synthesis of the fusarium toxin equisetin.

Organic letters·2000

Area of Science:

  • Polymer science
  • Materials science
  • Pharmaceutical technology

Background:

  • Polymeric microparticles are crucial for drug delivery.
  • Traditional methods often involve harsh solvents or surfactants.
  • Novel techniques are needed for controlled microparticle fabrication.

Purpose of the Study:

  • To prepare polymeric microparticles using compressed CO2 atomization (PCA).
  • To investigate the impact of process parameters on microparticle morphology.
  • To identify suitable polymers for the PCA process.

Main Methods:

  • Investigated polymer swelling in CO2 to prevent agglomeration.
  • Prepared poly(l-lactide) microparticles via PCA.
  • Varied CO2 pressure, temperature, flow rate, and polymer concentration.

Related Experiment Videos

Main Results:

  • Low glass transition temperature polymers agglomerated.
  • Optimal conditions for microparticle formation: moderate temperatures, low polymer concentration, high CO2 pressure, and high flow rates.
  • Achieved surfactant-free colloidal poly(l-lactide) particles; fibers formed at high concentrations/low flow rates.

Conclusions:

  • PCA is a promising technique for drug-containing microparticle preparation.
  • Advantages include tunable size/morphology, surfactant elimination, minimal residual solvents, and scalability.
  • Initial drug encapsulation efficiencies were low, requiring further optimization.