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[Fitz-Hugh and Curtis syndrome]
D Garcia Compean1, P Blanc, G d'Abrigeon
1Service d'Hépato-Gastroentérologie, Hôpital Saint-Eloi, Montpellier.
Presse Medicale (Paris, France : 1983)
|October 7, 1995
Summary
Fitz-Hugh and Curtis syndrome, a perihepatitis, is often caused by Chlamydia trachomatis. Early diagnosis via serology and laparoscopy, followed by antibiotic treatment, is key for effective management.
Area of Science:
- Hepatology
- Infectious Diseases
- Gynecology
Background:
- Fitz-Hugh and Curtis syndrome is characterized by perihepatic inflammation, often linked to pelvic inflammatory disease.
- Chlamydia trachomatis is a primary causative agent, particularly in developed nations, and a leading cause of salpingitis.
- Clinical presentation typically involves right upper quadrant pain, with normal liver function tests and imaging.
Purpose of the Study:
- To review the etiology, diagnosis, and management of Fitz-Hugh and Curtis syndrome.
- To highlight the role of Chlamydia trachomatis in the syndrome's pathogenesis.
- To discuss diagnostic modalities and treatment efficacy.
Main Methods:
- Review of clinical cases and diagnostic approaches for Fitz-Hugh and Curtis syndrome.
- Serological testing (indirect immunofluorescence, ELISA) for Chlamydia trachomatis diagnosis.
- Laparoscopic confirmation, including specimen culture and consideration of Polymerase Chain Reaction (PCR).
Main Results:
- Serological tests show high positive (80-90%) and negative (96-99%) predictive values for diagnosis.
- Laparoscopy frequently reveals perihepatitis with adhesions, inflammation, and fluid.
- Chlamydia trachomatis is the most common pathogen identified.
Conclusions:
- Fitz-Hugh and Curtis syndrome requires prompt diagnosis, often initiated by serology and confirmed laparoscopically.
- Effective antibiotic therapy is crucial for managing Chlamydia trachomatis infections causing perihepatitis.
- Advancements like PCR can improve Chlamydia detection, aiding in timely and accurate diagnosis.
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