Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pregnane glycosides from Stapelia variegata

K A el Sayed1, A F Halim, A M Zaghloul

  • 1Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Egypt.

Phytochemistry
|May 1, 1995
PubMed
Summary

Eleven new pregnane ester glycosides were isolated from Stapelia variegata. These compounds, including stavarosides A-K, were structurally elucidated using advanced spectroscopic methods.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A New Antileishmanial Preparation of Combined Solamargine and Solasonine Heals Cutaneous Leishmaniasis through Different Immunochemical Pathways.

Antimicrobial agents and chemotherapy·2016
Same author

Synthesis of 8-(3-Carboxy-l-methyl-propylammo)-6-methoxyquinoline: A Newly Characterized Primaquine Metabolite.

Pharmaceutical research·2013
Same author

Metabolism and distribution of primaquine in monkeys.

Pharmaceutical research·2013
Same author

Rapid aromatic hydrogen exchange in the antimalarial primaquine.

Pharmaceutical research·2013
Same author

Characterization of the urinary metabolites of primaquine in rats.

Pharmaceutical research·2013
Same author

Fungal metabolism of 4-methylprimaquine.

Pharmaceutical research·2013

Area of Science:

  • Natural Products Chemistry
  • Organic Chemistry
  • Phytochemistry

Background:

  • Stapelia variegata is a plant species known for its potential to produce bioactive compounds.
  • Pregnane ester glycosides are a class of natural products with diverse biological activities.
  • Previous research has identified various compounds from Stapelia species, but a comprehensive analysis of glycosides from S. variegata aerial parts is ongoing.

Purpose of the Study:

  • To isolate and characterize new pregnane ester glycosides from the aerial parts of Stapelia variegata.
  • To elucidate the chemical structures of the isolated compounds using spectroscopic techniques.
  • To contribute to the understanding of the chemical diversity of Stapelia species.

Main Methods:

  • Extraction of compounds from the aerial parts of Stapelia variegata.

Related Experiment Videos

  • Isolation and purification of glycosides using chromatographic techniques.
  • Structural elucidation using Nuclear Magnetic Resonance (NMR) spectroscopy, including Inverse Detected-Heteronuclear Multiple Bond Connectivity (HMBC) experiments, and Mass Spectrometry (MS).

    • Main Results:

    • Eleven new pregnane ester glycosides, named stavarosides A-K, were successfully isolated.
    • Eight compounds possessed a common trioside moiety, while the other three had a tetraside sugar moiety.
    • Detailed structural analysis confirmed the presence of unique ester linkages and glycosidic arrangements.

    Conclusions:

    • The study successfully identified eleven novel pregnane ester glycosides from Stapelia variegata.
    • The structural elucidation, particularly the assignment of ester positions, was significantly aided by HMBC experiments.
    • This research expands the known chemical profile of Stapelia species and provides valuable data for further pharmacological investigations.