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[Infantile spasms in children with Down's syndrome]
1Servicio de Neuropediatria, Hospital Sant Joan de Déu, Barcelona.
Revista De Neurologia
|March 1, 1995
Summary
Infantile spasms in infants with Down syndrome often show hypsarrhythmic electroencephalogram (EEG) patterns. While treatments like ACTH can be effective, developmental outcomes and behavioral issues persist despite EEG normalization.
Area of Science:
- Pediatric Neurology
- Clinical Electrophysiology
- Developmental Pediatrics
Context:
- Infantile spasms are a severe epilepsy syndrome in infants.
- Down syndrome is associated with an increased risk of epilepsy.
- Understanding epilepsy in Down syndrome is crucial for management.
Purpose:
- To analyze infantile spasms in infants with Down syndrome.
- To review EEG patterns, treatment responses, and neurodevelopmental outcomes.
- To identify challenges in managing epilepsy in this population.
Summary:
- Nine infants with Down syndrome presented with infantile spasms, predominantly with hypsarrhythmic EEG.
- Adrenocorticotropic hormone (ACTH) was the most effective treatment, with other antiepileptic drugs showing variable success.
- Despite EEG normalization and treatment response, developmental delays and behavioral problems were common.
Impact:
- Highlights the effectiveness of ACTH in infantile spasms in Down syndrome.
- Underscores the persistent developmental and behavioral challenges despite seizure control.
- Informs clinical practice regarding epilepsy management and developmental support for infants with Down syndrome.