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Vasculitis

R A Watts1, D G Scott

  • 1Ipswich Hospital NHS Trust, Department of Rheumatology, UK.

Bailliere'S Clinical Rheumatology
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

Systemic vasculitides are rare inflammatory blood vessel diseases. Recent classification criteria and assessment tools like the BVAS improve diagnosis and research comparability.

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Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Systemic vasculitides are rare inflammatory conditions affecting blood vessel walls, with an incidence approaching 40 per million annually.
  • Classification systems have evolved since 1952, incorporating vessel size, primary vs. secondary forms, and markers like ANCA.
  • Diagnostic criteria were established by the ACR in 1990, and nomenclature definitions by the Chapel Hill Consensus Conference in 1993/94.

Purpose of the Study:

  • To review the evolution of classification and diagnostic criteria for systemic vasculitides.
  • To highlight the importance of standardized criteria for research and clinical comparison.
  • To introduce current assessment tools for vasculitis activity and patient outcomes.

Main Methods:

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  • Review of historical and contemporary classification systems for systemic vasculitides.
  • Analysis of diagnostic criteria developed by the American College of Rheumatology (ACR) and the Chapel Hill Consensus Conference.
  • Discussion of assessment tools including the Birmingham Vasculitis Activity Score (BVAS) and SF-36 health status.

    • Main Results:

    • ACR criteria (1990) for specific vasculitides showed variable sensitivity (71.0-95.3%) and specificity (78.7-99.7%).
    • Chapel Hill Consensus definitions (1993/94) aim to standardize nomenclature and facilitate comparative studies.
    • Assessment tools like BVAS and SF-36 are under validation for measuring disease activity and quality of life.

    Conclusions:

    • Standardized classification and diagnostic criteria are crucial for advancing the study of systemic vasculitides.
    • Ongoing development and validation of assessment tools are essential for effective patient management and research.
    • Improved understanding and classification enhance the comparability of data across different research centers.