Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abnormal ventricular long-axis function in systemic sclerosis

M Y Henein1, J Cailes, C O'Sullivan

  • 1Royal Brompton Hospital, London, United Kingdom.

Chest
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Less paperwork and more practical approaches": An exploration of stakeholder opinions and priorities for UK postgraduate medical ultrasound education.

Radiography (London, England : 1995)·2025
Same author

Entrustable professional activities for physiotherapists to demonstrate digital health competency: an international delphi study.

Physiotherapy theory and practice·2025
Same author

Evaluation of a customised, AI-focused educational seminar delivered to final year undergraduate radiography students in the UK: A cross-sectional study.

Radiography (London, England : 1995)·2025
Same author

Reference values of strain-derived myocardial work indices in heart transplant patients.

European heart journal. Imaging methods and practice·2024
Same author

Unveiling the reliability of left atrial strain measurement: a dedicated speckle tracking software perspective in controls and cases.

European heart journal. Imaging methods and practice·2024
Same author

Selenium Deficiency as a Risk Factor for Peripartum Cardiomyopathy.

West African journal of medicine·2024

Systemic sclerosis frequently causes abnormal ventricular function, particularly in patients with pulmonary fibrosis. These cardiac abnormalities may stem from subendocardial myocardial fibrosis.

Area of Science:

  • Cardiology
  • Rheumatology
  • Pulmonology

Background:

  • Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis affecting multiple organs, including the heart.
  • Ventricular dysfunction can be a significant complication of SSc, impacting patient prognosis.

Purpose of the Study:

  • To evaluate the effects of systemic sclerosis on both right and left ventricular function.
  • To compare ventricular function in SSc patients with and without pulmonary fibrosis.

Main Methods:

  • Retrospective analysis of echocardiographic data from 34 SSc patients and 21 healthy controls.
  • Assessment of left and right ventricular long-axis function, transmitral, and transtricuspid Doppler flow velocities.

Main Results:

Related Experiment Videos

  • SSc patients exhibited reduced ventricular long-axis excursion and delayed contraction/relaxation.
  • Abnormalities were more pronounced in SSc patients with pulmonary fibrosis.
  • Both right and left ventricular function showed impairments, with specific findings like delayed filling and reduced acceleration times.

Conclusions:

  • Systemic sclerosis frequently leads to impaired ventricular long-axis function.
  • Pulmonary fibrosis exacerbates these cardiac abnormalities in SSc patients.
  • Subendocardial myocardial fibrosis is the likely cause of these observed ventricular dysfunctions.