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Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A
M D Aceto1, S M Scates, J A Lowe
1Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298-0613, USA.
European Journal of Pharmacology
|August 25, 1995
Abstract:
Precipitated withdrawal in rats chronically exposed to delta 9-tetrahydrocannabinol, the major psychoactive principle of the marijuana plant, was unequivocally demonstrated for the first time using a selective antagonist, SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1(2,4- dichloro-phenyl)-4-methyl-1H-pyrazole carboxamide.HCl). This demonstration should provide a powerful stimulus for the systematic study of dependency on the psychoactive cannabinoids.