Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pineoblastoma in adults

S M Chang1, P K Lillis-Hearne, D A Larson

  • 1Department of Neurological Surgery, University of California, School of Medicine, San Francisco, USA.

Neurosurgery
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic Significance of IDH1/2 Mutation and MGMT Promoter Methylation Status in RTOG 9813.

International journal of radiation oncology, biology, physics·2021
Same author

The role of fathers in overweight prevention: an analysis of a Caribbean cohort.

Global health, epidemiology and genomics·2018
Same author

Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns.

Veterinary pathology·2016
Same author

A SNP in the 3'-UTR of HSF1 in dairy cattle affects binding of target bta-miR-484.

Genetics and molecular research : GMR·2015
Same author

Bilaterally symmetric focal cortical dysplasia in a golden retriever dog.

Journal of comparative pathology·2014
Same author

Genome-wide normalized score: a novel algorithm to detect fetal trisomy 21 during non-invasive prenatal testing.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2014
Same journal

Performance of Risk Scores in Predicting Intracranial Aneurysm Instability.

Neurosurgery·2026
Same journal

Electric-Scooters: An Emerging Source of High-Severity Pediatric Head Trauma.

Neurosurgery·2026
Same journal

Survival After Surgery for Spinal Osteosarcoma and the Role of Chemotherapy and Treatment Sequencing: A National Cohort Multivariable Analysis.

Neurosurgery·2026
Same journal

Safety and Efficacy of 3-Month Versus 6-Month Duration of Dual Antiplatelet Therapy in Pipeline Embolization Treatment of Intracranial Aneurysms.

Neurosurgery·2026
Same journal

Risk Factors of Revision Surgery After Acute Proximal Junctional Fracture Following Adult Spinal Deformity Surgery.

Neurosurgery·2026
Same journal

Sensorimotor Network Alterations and Compensation in Cervical Spondylotic Myelopathy: A 7 T Task-Based and Resting-State Functional MRI Study.

Neurosurgery·2026
See all related articles

Staging pineoblastoma at diagnosis is crucial for prognosis. Patients with widespread disease at diagnosis had poorer outcomes than those with localized tumors.

Area of Science:

  • Neuro-oncology
  • Pediatric and Adult Brain Tumors
  • Clinical Neuroscience

Background:

  • Pineoblastomas are rare, aggressive primitive neuroectodermal tumors primarily affecting children, but also occurring in adults.
  • Accurate staging is essential for determining prognosis and guiding treatment strategies in neuro-oncology.
  • Previous staging protocols for pineoblastomas have varied, particularly in adult populations.

Purpose of the Study:

  • To report the outcomes of adult patients with pineoblastoma staged across the entire neuraxis at diagnosis.
  • To evaluate the prognostic significance of disease extent at diagnosis for pineoblastoma.
  • To recommend optimal initial staging procedures for pineoblastoma.

Main Methods:

  • Retrospective review of 11 adult patients (age > 16) with histologically confirmed pineoblastomas diagnosed between 1975 and 1992.

Related Experiment Videos

  • Neuraxis staging included cerebrospinal fluid examination and spinal magnetic resonance imaging.
  • Surgical resection extent and follow-up data were analyzed to correlate with patient outcomes.

    • Main Results:

    • All 11 patients presented with symptomatic hydrocephalus.
    • Five patients with positively staged disease (metastases) experienced progression and died within 1-20 months post-recurrence (median overall survival 30 months).
    • In contrast, five patients with negatively staged disease (no metastases) remained alive without progression after a median follow-up of 26 months.

    Conclusions:

    • The extent of pineoblastoma at diagnosis is a significant prognostic factor, similar to medulloblastomas and other primitive neuroectodermal tumors.
    • Comprehensive initial staging, including cerebrospinal fluid analysis and spinal MRI, is critical for adult pineoblastoma patients.
    • The benefit of adjuvant systemic chemotherapy following craniospinal irradiation for pineoblastomas remains uncertain.