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SAPHO syndrome

A Cotten1, R M Flipo, A Mentre

  • 1Department of Radiology, Hospital B, Centre Hospitalier Regional Universitaire de Lille, France.

Radiographics : a Review Publication of the Radiological Society of North America, Inc
|September 1, 1995
PubMed
Summary
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SAPHO syndrome links aseptic bone conditions with skin issues like palmoplantar pustulosis and acne. Awareness is key for radiologists to prevent misdiagnosis of this rare inflammatory disorder.

Area of Science:

  • Rheumatology
  • Dermatology
  • Radiology

Background:

  • SAPHO syndrome (Synovitis, Acne, Palmoplantar pustulosis, Hyperostosis, Osteitis) is a rare condition.
  • It involves aseptic skeletal lesions, sometimes without skin manifestations.

Purpose of the Study:

  • To describe the clinical and radiological features of SAPHO syndrome.
  • To highlight its association with skin conditions and skeletal findings.
  • To emphasize the importance of recognizing SAPHO syndrome for accurate diagnosis.

Main Methods:

  • Review of clinical and radiological data of patients with SAPHO syndrome.
  • Analysis of common and uncommon affected sites and lesion types.

Main Results:

Related Experiment Videos

  • The anterior chest wall is the most common site, showing osteosclerosis and hyperostosis.
  • Vertebral and sacroiliac involvement (sacroiliitis) are frequently observed.
  • Long bone and peripheral joint involvement can occur, typically without joint destruction.
  • Conclusions:

    • SAPHO syndrome presents with diverse skeletal manifestations, often linked to palmoplantar pustulosis and severe acne.
    • Radiological awareness is crucial to differentiate SAPHO syndrome from tumors or infections, avoiding unnecessary treatments.
    • A probable link to seronegative spondyloarthropathies suggests further research into its pathogenesis.