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Haematological profile in typhoid fever
1Department of Medicine and Clinical Pathology, Pt BD Sharma Medical College & Hospital, Haryana, India.
Tropical Doctor
|October 1, 1995
Summary
Typhoid fever significantly alters blood counts, causing anemia and low platelets. Bone marrow in patients shows impaired cell development and increased histiocyte activity.
Area of Science:
- Hematology
- Infectious Diseases
- Pathology
Background:
- Typhoid fever is a serious bacterial infection caused by Salmonella Typhi.
- Understanding its haematological impact is crucial for patient management.
Purpose of the Study:
- To investigate the haematological profile of patients with culture-proven typhoid fever.
- To identify specific changes in blood cell counts and bone marrow morphology.
Main Methods:
- Studied 20 culture-proven typhoid fever patients of diverse age and sex.
- Analyzed haematological parameters including blood cell counts.
- Examined bone marrow morphology.
Main Results:
- Observed significant anaemia, leucopenia, eosinopenia, and thrombocytopenia.
- Detected sub-clinical disseminated intravascular coagulation.
- Bone marrow revealed myeloid maturation arrest, reduced erythroblasts and megakaryocytes, and increased histiocyte phagocytic activity.
Conclusions:
- Typhoid fever causes significant haematological disturbances.
- Bone marrow changes reflect impaired haematopoiesis and inflammatory responses in typhoid fever.