[Reconstruction of the ossicle-tympanic system with a variable configuration prosthesis]

Area of Science:

• Otolaryngology
• Biomaterials Science
• Regenerative Medicine

Background:

• Chronic otitis media frequently results in auditory ossicle destruction.
• Reconstruction of ossicles is crucial for restoring hearing function.
• Existing prostheses may lack adaptability for diverse anatomical defects.

Purpose of the Study:

• To present a novel prosthesis for auditory ossicle reconstruction.
• To evaluate the efficacy of a variable configuration prosthesis in tympanoplasty.
• To address reconstruction challenges in chronic otitis media with ossicular defects.

Main Methods:

• Development of a prosthesis using human fetal flat bone with variable internal configuration.
• Application of the prosthesis in tympanoplasty for total/subtotal ossicular destruction and lateral attic wall defects.
• Assessment of morphological and functional outcomes post-reconstruction.

Main Results:

• The prosthesis design allows for adjustment to various tympanic ring region areas.
• Satisfactory morphological outcomes were achieved following reconstruction.
• Satisfactory functional outcomes were demonstrated, indicating successful hearing restoration.

Conclusions:

• The human fetal bone prosthesis offers a viable solution for ossicular reconstruction.
• The variable configuration enhances adaptability for complex anatomical reconstructions.
• This approach shows promise for improving surgical outcomes in chronic otitis media.