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Cervical thorium dioxide granuloma ('thorotrastoma')
B T Nguyen1, D M Yousem, R E Hayden
1Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
AJNR. American Journal of Neuroradiology
|September 1, 1995
Summary
A rare cervical thorium dioxide granuloma (thorotrastoma) caused an expanding mass compressing nerves and vessels. This diagnosis was confirmed histologically after imaging revealed a dense lesion from skull base to neck.
Area of Science:
- Radiology
- Pathology
- Oncology
Background:
- Thorium dioxide (Thorotrast) was historically used as a contrast agent.
- Delayed complications can arise years after administration.
- Cervical thorotrastomas are exceptionally rare.
Observation:
- An elderly woman presented with a progressively enlarging neck mass.
- Imaging revealed a dense lesion from the skull base to the lower neck.
- The mass encased cranial nerves, blood vessels, and muscles.
Findings:
- Radiographs showed a dense mass.
- MRI demonstrated mixed signal intensity.
- Histological examination confirmed a thorium dioxide granuloma (thorotrastoma).
Implications:
- Highlights the potential for delayed adverse effects of Thorotrast.
- Emphasizes the importance of considering iatrogenic causes for neck masses.
- Cervical thorotrastomas require accurate diagnosis for appropriate management.