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[Hypothyroidism followed by hyperthyroidism under treatment with amiodarone]
R C Martin-Du Pan1, M O Goumaz, C Perrotet
1Unité de la thyroïde, Hôpital cantonal, Genève.
Schweizerische Medizinische Wochenschrift
|November 6, 1993
Summary
Amiodarone treatment can cause both hypothyroidism and hyperthyroidism. Discontinuing amiodarone is recommended for managing these thyroid conditions.
Area of Science:
- Cardiology
- Endocrinology
- Pharmacology
Background:
- Amiodarone is an effective antiarrhythmic drug.
- Thyroid dysfunction is a known side effect of amiodarone therapy.
Observation:
- Two patients developed hypothyroidism after amiodarone treatment, followed by hyperthyroidism.
- Thyroid function normalized rapidly with antithyroid drugs and potassium perchlorate.
Findings:
- Amiodarone can induce both hypo- and hyperthyroidism.
- The physiopathology of amiodarone-induced hypothyroidism is complex.
Implications:
- Discontinuation of amiodarone is advised for patients experiencing amiodarone-induced thyroid dysfunction.
- Close monitoring of thyroid function is crucial in patients treated with amiodarone.