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Hyskon-induced pulmonary edema

¹Department of Anesthesiology, University of South Florida College of Medicine, Tampa 33612.

Surgery, Gynecology & Obstetrics

|December 1, 1993

Summary

Hyskon (dextran-70) may cause pulmonary edema by increasing lung fluid and protein leakage. This study in dogs suggests a non-cardiogenic mechanism for Hyskon-induced pulmonary edema.

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Area of Science:

Pulmonary Medicine
Cardiovascular Research
Medical Device Safety

Background:

Hyskon (dextran-70) is used for hysteroscopy to improve uterine visualization.
Pulmonary edema of unknown origin has been reported in patients post-hysteroscopy.
The mechanism of Hyskon-induced pulmonary edema requires investigation.

Purpose of the Study:

To determine if Hyskon causes cardiogenic or non-cardiogenic pulmonary edema.
To investigate the effect of Hyskon on pulmonary microvascular permeability using a canine model.

Main Methods:

Dogs were infused with Hyskon or whole blood to maintain specific left ventricular end-diastolic pressure.
Bronchoalveolar lavage (BAL) and plasma protein levels were measured.
Pulmonary microvascular membrane permeability was assessed by the BAL protein to plasma protein ratio.

Main Results:

Dogs receiving Hyskon showed increased protein in BAL fluid post-infusion.
The ratio of BAL protein to plasma protein was significantly higher in the Hyskon group compared to the blood group.
Hyskon administration altered pulmonary microvascular membrane permeability.

Conclusions:

Hyskon can cause pulmonary edema through increased leakage of plasma proteins into the alveoli.
The study suggests a significant non-cardiogenic component in Hyskon-induced pulmonary edema.
Findings indicate Hyskon may contribute to the observed pulmonary complications in patients.

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