Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interaction between neutrophils and endothelium

M J Elliott1, A H Finn

  • 1Hospital for Sick Children, London, England.

The Annals of Thoracic Surgery
|December 1, 1993
PubMed
Summary

Cardiopulmonary bypass in children triggers an inflammatory response, increasing neutrophil adhesion to the endothelium. This capillary leak is linked to changes in adhesion molecules and interleukin-8, requiring further research for clinical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive tumor-agnostic evaluation of genomic and epigenomic-based approaches for the identification of circulating tumor DNA in early-stage breast cancer.

ESMO open·2025
Same author

The multi-disciplinary management of complex congenital and acquired tracheo-oesophageal fistulae.

Pediatric surgery international·2018
Same author

Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer.

Proceedings of the National Academy of Sciences of the United States of America·2018
Same author

Validation of the Airway-Dyspnoea-Voice-Swallow (ADVS) scale and Patient-Reported Outcome Measure (PROM) as disease-specific instruments in paediatric laryngotracheal stenosis.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2016
Same author

Reply to: "Recent Advances in Circumferential Tracheal Replacement and Transplantation".

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet.

Journal of perinatology : official journal of the California Perinatal Association·2015

Area of Science:

  • Pediatric cardiovascular surgery
  • Inflammatory response
  • Endothelial permeability

Background:

  • Cardiopulmonary bypass (CPB) in children can induce endothelial dysfunction.
  • Neutrophil-endothelial interactions are key to capillary leak during CPB.
  • Understanding these interactions is crucial for managing CPB-related complications.

Purpose of the Study:

  • To review mechanisms of neutrophil-endothelial adhesion during pediatric CPB.
  • To examine evidence for modulation of these adhesion processes.
  • To investigate the role of specific adhesion molecules and cytokines.

Main Methods:

  • Review of current literature on neutrophil-endothelial adhesion.
  • Analysis of changes in L-selectin and CD11b/CD18 expression during pediatric CPB.
  • In vitro studies on the effects of CPB-associated factors on adhesion molecules and interleukin-8.

Main Results:

  • CPB in children is associated with decreased L-selectin and increased CD11b/CD18 expression.
  • Interleukin-8 may play a role in modulating neutrophil-endothelial adhesion.
  • CPB procedures (temperature, circulation changes) up-regulate adhesion molecules and interleukin-8 release in vitro.

Conclusions:

  • Pediatric CPB induces significant changes in neutrophil adhesion molecule expression.
  • Cytokines like interleukin-8 and procedural factors influence these adhesion mechanisms.
  • Further research is needed to define precise mechanisms and clinical correlations.

Related Experiment Videos