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Related Experiment Videos

Nimesulide in dysmenorrhoea

M Pulkkinen1

  • 1Department of Obstetrics and Gynaecology, University of Turku, Finland.

Drugs
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Nimesulide effectively alleviates pain in women with dysmenorrhea within 30 minutes. This non-steroidal anti-inflammatory drug reduces uterine pressure and prostaglandin F2 alpha levels, offering significant pain relief.

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Area of Science:

  • Pharmacology
  • Gynecology
  • Pain Management

Background:

  • Dysmenorrhea is characterized by high resting intrauterine pressure, particularly in the fundus.
  • Painful uterine contractures are a hallmark of dysmenorrhea.

Purpose of the Study:

  • To investigate the effects of nimesulide on intrauterine pressure and pain in dysmenorrheic patients.
  • To assess the pharmacokinetic profile and tissue distribution of nimesulide in female genital tissues.
  • To evaluate the impact of nimesulide on prostaglandin F2 alpha levels during menstruation.

Main Methods:

  • Oral administration of nimesulide (100mg) in a double-blind, placebo-controlled, cross-over study.
  • Measurement of active intrauterine pressure using microsensors.
  • Assessment of pain levels and prostaglandin F2 alpha concentrations in menstrual blood.

Related Experiment Videos

  • Pharmacokinetic analysis of nimesulide distribution in uterine and ovarian tissues.

    • Main Results:

    • Nimesulide significantly alleviated pain within 30 minutes without affecting the direction or velocity of uterine activity.
    • The drug reduced maximal intrauterine pressure during painful periods, converting contractures to painless contractions.
    • Nimesulide demonstrated even distribution in female genital tissues, with peak concentrations at 3 hours.
    • Prostaglandin F2 alpha levels were significantly reduced from 382 to 94 micrograms/L after nimesulide administration.

    Conclusions:

    • Nimesulide provides effective pain relief for dysmenorrhea by reducing intrauterine pressure and prostaglandin F2 alpha levels.
    • The drug exhibits favorable pharmacokinetics, distributing well into reproductive tissues.
    • Nimesulide offers a therapeutic option for managing pain associated with dysmenorrhea.