Bone marrow clastogenicity of trimethyltin

Aqueous solutions of trimethyltin in four different concentrations were administered i.p. for three different treatment periods, to five Swiss albino male mice for each experimental set. Bone marrow cells were processed for somatic chromosome preparation after 6, 18 and 24 h following the usual protocol. Structural abnormalities including chromatid and chromosome breaks, dicentrics, rings and fragments were recorded. Critical assessment of the data with the one-tailed trend test revealed a significant positive trend of the dose effects in all three treatment periods. With the ANOVA test, significant variations in aberrations were observed between chemical concentrations and between treatment periods and their interaction (dose x time) was significant in aberrations and mitotic indices. Depression of mitotic index was dose- and duration-dependent.