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Updated: Jul 29, 2026

Isolation and Characterization of Neutrophils with Anti-Tumor Properties
Published on: June 19, 2015
A tumor cell line producing granulocyte colony-stimulating factor and an immune suppressive factor
M Tsukuda1, T Nagahara, Y Mikami
1Department of Otorhinolaryngology, Yokohama City University, School of Medicine, Kanagawa, Japan.
Abstract:
From a patient, both a cell line incapable of secreting granulocyte colony-stimulating factor (G-CSF) (TC873) and a cell line capable of secreting G-CSF (TCM902) were established. The effector cells induced, with TC873 cells showed a high lytic capacity against two types of tumor cells. The effector cells induced by TCM902 cells did not show such capacity. Furthermore, the TCM902 cells excreted a factor suppressing the proliferation of lymphokine activated killer (LAK) cells and the autologous tumor cell lysis of tumor associated lymphocytes. This factor probably is TFG-beta 1.
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