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Cutaneous plexiform schwannoma in a pig
1Chuo Meat Inspection Laboratory, Kochi Prefecture, Japan.
Journal of Comparative Pathology
|October 1, 1993
Summary
This study reports the first case of plexiform schwannoma in a domestic animal, a 6-month-old pig. The tumor showed characteristics of both Schwann cells and perineurial cells, suggesting a potential shared cell origin.
Area of Science:
- Veterinary Pathology
- Oncology
- Comparative Pathology
Background:
- Plexiform schwannoma (PFS) is a rare nerve sheath tumor.
- Understanding PFS in animals aids comparative oncology and veterinary diagnostics.
Purpose of the Study:
- To document and characterize the first reported case of plexiform schwannoma in a domestic animal.
- To investigate the cellular origin and immunohistochemical profile of the tumor.
Main Methods:
- Histopathological examination of a dermal mass from a pig.
- Immunohistochemical analysis using S-100 protein, vimentin, and cytokeratin.
- Ultrastructural evaluation of neoplastic cells.
Main Results:
- The tumor exhibited features of Antoni A and B types, with neoplastic cells positive for S-100 protein and vimentin.
- Peripheral cells showed cytokeratin positivity, similar to normal swine perineurial cells.
- Double immunostaining indicated neoplastic cells expressing both S-100 and cytokeratin, suggesting a common cell lineage.
Conclusions:
- This case represents the first documented plexiform schwannoma in a domestic animal.
- The findings suggest that S-100-positive Schwann cells and cytokeratin-positive perineurial cells may be functional variants of the same cell type.
- The tumor shares similarities with human plexiform schwannoma but exhibits distinct features.