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Substance P containing polymer implants protect against striatal excitotoxicity
P R Sanberg1, D F Emerich, P Aebischer
1Department of Surgery, University of South Florida, College of Medicine, Tampa 33612.
Brain Research
|November 19, 1993
Summary
Substance P (Sub P) demonstrated neuroprotection against quinolinic acid (QA)-induced striatal damage. Slow-release Sub P rods prevented QA-induced loss of dopamine D1 receptors, highlighting Sub P
Area of Science:
- Neuroscience
- Pharmacology
- Neuroprotection
Background:
- Quinolinic acid (QA) is a neurotoxin that can induce excitotoxicity in the striatum.
- Dopamine D1 receptors are crucial in striatal function and are vulnerable to QA-induced damage.
Purpose of the Study:
- To investigate the potential neuroprotective effects of substance P (Sub P) against QA-induced excitotoxicity in the rat striatum.
- To assess the impact of Sub P on dopamine D1 receptor levels following QA administration.
Main Methods:
- Substance P (Sub P) was delivered via slow-release polymer rods implanted unilaterally into the rat striatum.
- Animals received intrastriatal injections of varying doses of quinolinic acid (QA) (50, 75, or 100 nmol/microliters) or QA alone (controls).
- Dopamine D1 receptor levels in the striatum were measured three weeks post-injection.
Main Results:
- Quinolinic acid (QA) administration resulted in a dose-dependent loss of striatal dopamine D1 receptors.
- Substance P (Sub P) delivery via slow-release rods significantly protected the striatum from QA-induced D1 receptor loss.
- These findings indicate a protective role for Sub P in mitigating excitotoxic injury.
Conclusions:
- Substance P (Sub P) exhibits significant neuroprotective properties against quinolinic acid (QA)-induced excitotoxicity in the striatum.
- Slow-release delivery of Sub P is effective in preserving dopamine D1 receptor integrity.
- Sub P represents a potential therapeutic agent for conditions involving excitotoxic neurodegeneration.