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Related Experiment Videos

Growth hormone-binding proteins in plasma

G Baumann1, M Mercado

  • 1Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611.

Nutrition (Burbank, Los Angeles County, Calif.)
|November 1, 1993
PubMed
Summary

Growth hormone-binding proteins (GHBPs) influence growth hormone action by binding to GH and extending its half-life. Their levels are linked to GH action and are affected by nutritional status, impacting growth.

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Human Physiology

Background:

  • Two distinct growth hormone-binding proteins (GHBPs) with high and low affinities exist in circulation.
  • The high-affinity GHBP is a soluble fragment of the growth hormone receptor (GHR).
  • GHBPs modulate growth hormone (GH) bioavailability, half-life, and receptor interactions.

Purpose of the Study:

  • To elucidate the role of GHBPs in regulating GH action.
  • To investigate the relationship between GHBP levels and various physiological and pathological conditions.
  • To understand the nutritional regulation of GHBP and its impact on GH axis function.

Main Methods:

  • Analysis of GHBP levels in human plasma.
  • Correlation of GHBP levels with clinical conditions affecting GH action.
  • Investigation of nutritional influences on GHBP/receptor levels.

Main Results:

  • GHBPs enhance overall GH action in vivo.
  • Plasma GHBP levels correlate with tissue receptor concentrations.
  • Altered GHBP levels are observed in conditions like Laron-type dwarfism, malnutrition, and diabetes.
  • GHBP levels exhibit nutritional regulation, being low in undernutrition and high in overnutrition.

Conclusions:

  • GHBPs play a crucial role in modulating GH bioavailability and action.
  • GHBP levels serve as indicators of GH receptor status and GH axis function.
  • Nutritional status significantly impacts GHBP levels, explaining growth abnormalities in metabolic disorders.

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