Related Experiment Videos
Adhesion molecule expression in chronic inflammatory periodontal disease tissue
E Gemmell1, L J Walsh, N W Savage
1Department of Dentistry, University of Queensland, Australia.
Journal of Periodontal Research
|January 1, 1994
Summary
Adhesion molecule expression on mononuclear cells in gingival tissues did not differ significantly between gingivitis and periodontitis. This suggests no differential role for these molecules in lymphocyte trafficking in these distinct inflammatory conditions.
Area of Science:
- Oral immunology
- Periodontal disease pathogenesis
Background:
- Lymphocyte populations differ in gingivitis and periodontitis.
- Adhesion molecules may influence lymphocyte movement in oral tissues.
Purpose of the Study:
- To investigate differential expression of adhesion molecules on lymphocytes in gingivitis versus periodontitis.
- To assess the role of adhesion molecules in lymphocyte trafficking in these conditions.
Main Methods:
- Immunohistochemical staining of gingival biopsies (n=21) using avidin-biotin technique.
- Analysis of adhesion molecule expression (ICAM-1, PECAM-1, LECAM-1) on mononuclear cells.
- Grouping specimens by infiltrate size and disease status (gingivitis/periodontitis).
Main Results:
- Expression of ICAM-1, PECAM-1, and LECAM-1 on mononuclear cells increased with infiltrate size.
- No significant differences in mononuclear cell adhesion molecule expression between gingivitis and periodontitis groups.
- Endothelial cells showed varied expression patterns, while keratinocytes exhibited increased ICAM-1 with infiltrate size.
Conclusions:
- Adhesion molecule expression on lymphocytes does not appear to differ between gingivitis and periodontitis tissues.
- Findings do not support a differential role for these adhesion molecules in lymphocyte trafficking in these distinct oral inflammatory diseases.