[Effect of genetic structure on hereditary diseases in Russian populations]

Several characteristics of the lead of hereditary diseases can be distinguished. These include: the mean values of a prevalent autosomal dominant; autosomal recessive and X-linked recessive disorders in a population; the spatial distribution of families with hereditary diseases, especially those with autosomal recessive disorders in a population; and diverse hereditary pathologies in the population. All these characteristics are shown to be influenced by the genetic pattern of Russian populations, namely by random inbreeding which varies significantly in northern rural populations, but which is virtually equal to 0 in northern urban and southern Russian populations. The rate of migration is another factor of the genetic pattern which also affects the load of hereditary diseases.