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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

[Apoptosis in immunology]

T Tadakuma1

  • 1Dept. of Microbiology, Keio University School of Medicine, Tokyo, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|April 1, 1994
PubMed

Apoptosis is the physiological cell death, and recent studies have revealed that apoptosis plays an important role in the various fields of immunology. Especially, in the formation of T or B cell repertoires, the cells reactive to self antigens are eliminated by the induction of apoptosis, whereas the cells competent to react against foreign antigens are saved for survival by the suppression of apoptosis. Furthermore, apoptosis is employed as the destruction mechanism of target cells in killer T cells or NK cells. The disturbance of apoptosis-mechanism, therefore, will be strongly relevant for the etiology of autoimmune diseases and carcinogenesis.

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