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Related Experiment Videos

The acute phase response

H Baumann1, J Gauldie

  • 1Dept of Molecular and Cell Biology, Roswell Park Cancer Institute, Buffalo, NY 14263.

Immunology Today
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Adult mammals initiate an acute phase response to tissue damage, involving physiological reactions. This review details the cellular and molecular control of injury response, systemic defense recruitment, liver acute phase reaction, and response resolution.

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Area of Science:

  • Physiology
  • Immunology
  • Cell Biology

Background:

  • Adult mammals exhibit a coordinated physiological reaction to tissue damage known as the acute phase response (APR).
  • The APR involves complex cellular and molecular signaling pathways to manage injury and restore homeostasis.

Purpose of the Study:

  • To review the key cellular and molecular mechanisms governing the acute phase response in adult mammals.
  • To elucidate the initiation, systemic recruitment, hepatic response, and resolution phases of the APR.

Main Methods:

  • Literature review of cellular and molecular studies on tissue injury and the acute phase response.
  • Synthesis of findings on signaling pathways, immune cell involvement, and hepatic gene expression.

Main Results:

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  • Detailed mechanisms of initiating the localized tissue response at the injury site.
  • Explanation of how systemic defense mechanisms are recruited.
  • Description of the liver's role in producing acute phase proteins.
  • Overview of the processes involved in resolving the acute phase response.

Conclusions:

  • The acute phase response is a critical, multi-faceted process essential for mammalian survival following tissue damage.
  • Understanding these mechanisms provides insights into inflammatory diseases and therapeutic targets.