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Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment
1Herman B Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Indianapolis, IN.
Blood
|April 15, 1994
Summary
Interleukin-11 (IL-11) is a growth factor with distinct effects on hematopoietic and nonhematopoietic cells. Human trials will clarify its role in chemotherapy and physiology.
Area of Science:
- Hematology
- Cell Biology
- Pharmacology
Background:
- Interleukin-11 (IL-11) is a growth factor with unique bioactivity.
- IL-11 exhibits distinct biological profiles compared to Interleukin-6 (IL-6).
Purpose of the Study:
- To explore the pleiotropic effects of IL-11 on hematopoietic cells.
- To investigate the impact of IL-11 on nonhematopoietic cells, including neurons and stem cells.
- To evaluate the pharmacologic effects of IL-11 in human trials during chemotherapy.
Main Methods:
- Comparison of IL-11 and IL-6 bioactivity.
- Observation of IL-11 effects in various cellular environments.
- Analysis of IL-11's impact on nonhematopoietic cell types.
- Initiation of human clinical trials for IL-11 assessment.
Main Results:
- IL-11 demonstrates pleiotropic effects on hematopoietic cells, influenced by cellular context.
- IL-11 significantly impacts nonhematopoietic cells like neurons, intestinal stem cells, and preadipocytes.
- General findings regarding IL-11's effects are consistent across studies.
Conclusions:
- IL-11 possesses diverse biological activities affecting both hematopoietic and nonhematopoietic systems.
- Human trials are expected to elucidate IL-11's therapeutic potential and physiological roles.
- Ongoing gene targeting experiments in mice aim to further define IL-11's functions.